Guidelines for Genetic Research

This outline is intended to help the investigator prepare a submission for Genetic Research. If your study conforms to all of the points listed below, then you meet the guideline requirements for Genetic Research. If your study does not conform to this outline, please consult with the PHRC staff office (617-424-4100) regarding areas of
non-conformity.

Genetic Research is defined as research conducted by investigators solely for the purpose of generating scientific knowledge about genes and/or the genetic basis of disease. This research is not intended to provide subjects or their families with specific information about their genetic status or health, and at no time should this information be divulged by the investigator, without following the guidelines provided.

GENETIC RESEARCH OUTLINE

Disclosure of Research Results & Confidentiality	State that this study is for research purposes only and no individual results will be given back to study participants. This will include information from final results of the study, interim results of the study and incidental findings. State that research results will never go into the medical record. State that confidentiality will be preserved to the fullest extent by the research team.
Tissue Samples	State that if identifiers are to be maintained, they will be kept in a separate, secure locked location. Describe the security system on the computer, if the data is to be entered into a database. State that samples will be coded in order to remain confidential.
Provisions for future contact (re-contact); Primary Use of Sample	State (if applicable) that the samples collected for this study may yield information that could be clinically relevant. Provide an option to be re-contacted if research information becomes applicable to clinical diagnosis/treatment. State that such contact could, if desired, lead to referral involving outside parties (e.g., a genetics clinic). State that additional consent will be necessary to transfer research data to the clinical setting. This consent must be submitted for review and approval. State that the investigators are not obligated to keep addresses/contact information in order to re-contact the subject.
Special issues: Secondary Uses Third Party Uses	A secondary use is using a collected sample for any reasons other than the intended and documented purpose. A third party is any person outside the immediate research team. All secondary and third party uses of biological samples are restricted to anonymized or anonymous samples. This means the sample cannot be identified or linked to an individual by the ‘secondary-use-researcher’ or the ‘third party’. Limited, non-identifying, demographic information may be retained on the sample. Non-anonymous secondary research must follow the Genetic Research Guidelines.

Special Issues Concerning

Protocol Development for Genetic Research Studies

(see the Guidelines for Genetic Research before using this to develop your protocol)

1. Purpose of Study or Activity

Provide a concise statement about the background, nature and scientific justification for the proposed study or activity. Enough information must be given for the scientific design to be made clear to those who review the proposal. Cite appropriate references.

2. Protocol for Study or Plan of Activity

Indicate source of patients and controls, recruiting procedures and discuss any financial compensation or remuneration planned for subjects. Include copies of recruitment letters to be used in the study. Describe inclusion and exclusion criteria for study participation. Describe the actual research studies or activities to be carried out that will involve the use of samples donated by human subjects.

For genetic studies involving acquisition of biological samples:

Describe the procedures to be used to obtain samples. Describe the type, amount and/or size of sample(s) to be taken. Explain whether or not identifiers will be maintained and how patient confidentiality will be assured. Describe how researchers will deal with sample/storage failure. Indicate if recontact will/might be made for additional samples. Indicate if procedures are in place for the participant to request their sample/cell line be destroyed or stripped of identifiers. Indicate how samples will be coded. State (if applicable) that samples may be used for research purposes other than the specified disorder, but will remain coded and anonymous to the research. Characterize what these other uses may be. State (if applicable) that samples may be shared with third parties but will be sent out coded and remain completely anonymous to the third party. The MGH will not allow an identified sample to be shared with third parties.

State that this study is for research purposes only and no individual results will be given back to study participants. This will include information from final results of the study, interim results, and incidental findings. State that record of participation (including a consent form and research results) will never go into the medical record.

Consider what you would like to do if clinically relevant information might eventually become available from your research. Do you need procedures in place to effectively communicate to the population of participants that relevant genetic information may be available? Any communication must not be informative regarding specific results.

3. Interpretation of Data

Indicate clearly how the proposal will answer the hypothesis being tested. Include statistical considerations related to the proposed sample size, data interpretation, etc.

4. Risks, Discomforts, and Potential Benefits

Describe the potential risks and discomforts as well as potential benefits that would attend participation in the study. Bear in mind that the study should be designed to achieve its goal with the least possible risk to subjects. Do not understate the risks or overstate the potential benefits. There should be no disclosure of study results to participating subjects and therefore no significant non-medical risks associated, if care is given to issues of confidentiality.

5. Confidentiality

Mention the ways in which the rights and welfare of the subjects will be protected. State that confidentiality will be preserved to the fullest extent by the research team, however that this cannot be guaranteed. State that research study participation information including research results will not be given to family members, insurance companies, employers or other third parties without written permission of the subject and IRB approval. Any shared samples must be anonymized to the recipient.

If samples are to be collected using "mailers", describe the procedures in place to avoid unintentional disclosure as can occur if an insurance company is billed for the phlebotomy.

6. Informed Consent and Documentation of Informed Consent

Describe the manner in which informed consent will be obtained from subjects who will participate in the proposed studies or activities. Provide a copy of your written informed consent document for SHS approval. Include in both your protocol submission and informed consent document the following elements:

A. State that informed consent is for  genetic research purposes and will not appear in the medical record.

B. State that specific information resulting from genetic research will not be available to participants and their families.

C. Include information about the DNA sample to be taken, including whether or not cell lines will be established. Detail how the cell line/DNA sample will be used. Consider offering the participant the option of allowing samples to be shared or not.

D. Explain if samples will be shared with other investigators (third parties). Indicate that shared samples will be anonymous to the other investigators. Consider offering the participant the option of allowing samples to be shared or not.

E. Indicate if samples will be used for secondary uses. In other words, research other than for what it was collected. Secondary uses may only be done on anonymized or anonymous samples.

F. If you have a Newsletter or other means to communicate general information regarding research results (e.g., new gene mutation discovered in X disorder), offer participants the option of receiving general information. No information should be directed specifically to, or communicated directly, to a participant.

G. Two copies of the informed consent should exist. An original copy should be filed in the research files and a second copy for the participant.